in vitro allergy assays that enable allergy testing without risk of a patient reaction. An extensive range of allergens are also available.
Cellular Allergen Stimulation Test (CAST) systems for laboratory allergy testing - choose from ELISA format or the basophil activation whole blood flow cytometry assay.
Allergens include: food, drugs, insect venoms, environmental factors etc.
The most often presumed etiology of life-threatening anaphylactic reactions is food (33%), insect venoms (14%) and medications (13%). Identification of the allergens causing immediate type reactions can be a very difficult task for allergologists. The most common method of investigation usually starts with the patient history followed by skin tests and blood tests. However, in numerous cases the results of these tests are not absolute, making a provocation test necessary. This carries a risk of an anaphylactic event.
In vitro allergy testing has become important in reducing the number
of time consuming, costly and potentially harmful in vivo challenges to
determine allergy specificity in patients.
Using the BÜHLMANN CAST® range of Allergy assays can significantly decrease the amount of provocation tests that need to be performed.
In some cases, specific IgE fails to demonstrate absolute diagnostic reliability. This happens mainly in more complex reactions such as drug, venom or food allergies. The CAST® (Cellular Allergen Stimulation Test) allergy assays will identify both IgE and non-IgE allergies.
The BÜHLMANN CAST® assays detect immediate type allergic reactions and hypersensitivities to suspected allergens.
Using an in vitro allergy test protects the patient by avoiding the risk of an anaphylactic response that can occur using traditional in vivo tests.
Road map for the clinical application of the basophil activation test in food allergy
Santos, A.F. and Shreffler, W.G. Clin. & Exp. Allergy Volume 47, Issue 9, September 2017, Pages 1115–1124