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Cryptococcal antigen (CrAg) assays

Detection of Cryptococcal Antigens (CrAg) has been the primary method for laboratory diagnosis of a current infection. 

We offer two solutions for the detection of CrAg:

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Cryptococcosis is an opportunistic infection caused by fungi of the genus Cryptococcus. Individuals with an impaired cell mediated immune system are at particular risk of infection, and the disease is especially prevalent among those infected with HIV who have developed AIDS.

The incidence is rising due to the increase in the number of patients who are:

  • On Chemotherapy
  • with HIV infection
  • On anti-rejection drugs following transplantation.
  • Cryptococcus fungal infections can remain undetected until symptoms become apparent. Then they are very difficult to treat.

    Cryptococcosis is the fourth most common cause of death amongst AIDS patients globally.

    Cryptococcus Lateral Flow Assay

    Traditional methods of diagnosing Cryptococcosis can be technically complex, require sample pre-treatment and can take an hour or more to deliver results. The Cryptococcus antigen (CrAg) Lateral Flow Assay has been developed to overcome these issues. It is an immunochromatographic test for detection of the capsular polysaccharide antigens of Cryptococcus species in serum and cerebrospinal fluid (CSF).

    Cryptococcus Lateral Flow Assay

    The assay represents a dramatic improvement on other methods and features.

  • Simple lateral flow test in dipstick-sandwich format
  • Delivers a clear result in 10 minutes, no sample pretreatment required
  • More sensitive than any other CrAg assay
  • Offers qualitative or semi quantitative detection
  • The test provides an unequivocal positive or negative result for the presence/absence of CrAg in serum or CSF. As such it makes diagnosis of Cryptococcosis rapid, simple and reliable.

    • CrAg® LFA for the detection of Crytococcal Antigen

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    How to stop 'crypto,' a deadly disease so neglected it's not even on the 'neglected' list

    Public Radio International article
    http://www.pri.org/stories/2016-01-13/how-stop-crypto-deadly-disease-so-neglected-its-not-even-neglected-list

     

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