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IBDoc® Calprotectin Home Testing

Supporting New Standards of Care for IBD with the first CE marked Calprotectin Patient Self-Test


IBDoc provides a customised, patient centric approach for management of disease and therapy.

Easy as 1-2-3 

The new BÜHLMANN IBDoc® system, now available from Alpha Laboratories, provides sophisticated technology that enables your IBD patients to perform quantitative calprotectin testing themselves, in just three easy steps, reading the results using their smartphones.

  1. Process the sample with the CALEX® Valve extraction device.
  2. Apply the extracted sample to the calprotectin cassette
  3. Use the smartphone CalApp® to read and calculate the result and send it to the gastroenterologist via the secure IBDoc® Portal.

More Regular Patient Monitoring

IBDoc provides a practical way for more frequent monitoring of patients in the privacy of their own home.

Under the guidance of clinicians, more regular patient monitoring can help predict potential relapse and assist in therapy optimisation. This approach allows for a customised, patient centric approach for management of disease and therapy.

 IBDOC Step 1IBDOC Step 2IBDOC Step 3

IBDocTest Procedure

IBDoc Calprotectin Home Test Step 1
1. Prepare the Test 
To start the test procedure the patient logs into the downloaded CalApp® on their smartphone with their IBDoc® account username and password.  They then collect a stool sample with the easy to use faecal collection paper sheet included in the IBDoc® Test Kit.

IBDoc Calprotectin Home Test Step 2
2. Extract the Sample
The sampling pin of the CALEX® Valve extraction device is dipped into the stool sample a few times with a twisting motion. This collects a defined amount of stool in the grooves of the CALEX® Valve pin. The pin is placed back into the tube through the upper funnel.

IBDoc Calprotectin Home Test Step 3
3. Load the Test Cassette
The CALEX® Valve tube is applied onto the test cassette and a precise amount of extract is released by turning the lever. After a few seconds, when the membrane strip of the cassette gets visibly soaked, the lever is closed.

IBDoc Test Procedure Step 4
4 Read the Test Cassette
Results are read using the smartphone camera. Placing the camera above the cassette focuses and automatically takes a picture. The image is analysed through a sophisticated image processor and a quantitative result is calculated by the CalApp®.

IBDoc Test Procedure Step 5
5 Save the Test Result

Using a traffic light code system the result is classified as NORMAL, MODERATE, or HIGH. All the results performed on one smartphone are saved locally and can be accessed at any future time.

IBDoc Test Procedure Step 6
6 Doctor Is Notified
The result taken with the CalApp® is automatically transferred to the IBDoc® Portal and the patient’s doctor is immediately notified. Depending on the test result the doctor can communicate with the patient to advise on further therapeutic steps to be taken.


  • First CE marked Calprotectin Home Test
  • Excellent correlation with laboratory based tests
  • Quantitative rapid test with measurement of calprotectin in the range 30 – 1000µg/g
  • Simple sample preparation devices minimises pre-analytical errors
  • All components contained within the kit to perform a test with simple instructions
    Pictorial IFU guide
    Two stool collection papers
    Camera calibration card/ reading template
    CALEX value extraction device
    Individually sealed test cassette
  • User friendly App with Phone calibration

Easy Sample Extraction and Dispensing

The CALEX® Valve allows patients to process their own samples without the need for vortex mixing, centrifuging or pipetting. The valve at the base of the device dispenses a precise amount of liquid onto the lateral flow test device. After 12 minutes the calprotectin assay result is read using the smartphone and the data is transmitted to the clinician via a secure web portal.

IBDOC Step 1

Personal Portal for Direct Management by the Clinican

The IBDoc Portal is a secure, encrypted, user friendly application for clinical professionals to manage their IBD patients.
Each patient test profile can be tailored by the clinician:

  • Threshold values for the traffic light system
  • Choose for the patient to see the traffic light interpretation, the actual calprotectin value or hide the results completely
  • Set the frequency of the tests for the patient.

Excellent Correlation of Results 

IBDoc provides consistent results that correlate with other BÜHLMANN Calprotectin assays:

  1. BÜHLMANN Quantum Blue® fCAL
  3. BÜHLMANN fCAL® turbo

IBDoc Correlation of Results

  • Big Changes Coming Soon to a Clinic Near You - Calprotectin Testing Goes Mobile

    • PDF size: 11.17KB
    • Updated on: 05/09/2018

    Article featured in Clinical Services Journal - September 2018

    Open File
  • Calprotectin Revolution and Evolution

    • PDF size: 12.37KB
    • Updated on: 04/07/2018

    Open File
  • IBDoc Brochure

    • PDF size: 9.55KB
    • Updated on: 04/07/2018

    A Step Forward Towards Patient Empowerment

    Open File
  • IBDoc Calprotectin Home Test Flyer

    • PDF size: 9.83KB
    • Updated on: 24/12/2018

    Including a list of compatible phones

    Open File
  • IBD Management - Power to the Patient

    • PDF size: 8.92KB
    • Updated on: 04/07/2018

    Open File
  • IBDoc Instructions for Use

    • PDF size: 4.59KB
    • Updated on: 04/07/2018

    Open File
  • IBDoc Quick Guide Version 1.6

    • PDF size: 1.76MB
    • Updated on: 11/09/2018

    Open File
  • Introducing Patient Home Tests for Calprotectin in a Routine District General Hospital

    • PDF size: 10.48KB
    • Updated on: 18/07/2018

    Pearl Avery, Lead Inflammatory Bowel Disease Nurse, Dorset County Hospital and Gastrointestinal/IBD Nurse of the Year 2018

    Open File
  • New faecal calprotectin cut-off points for remission and active disease defined by UCEIS and Nancy indices in ulcerative colitis (UC)

    • PDF size: 9.22KB
    • Updated on: 03/08/2018

    Walsh A. et al. ECCO P262

    Open File
  • Cost Effective Monitoring

    • PDF size: 8.16KB
    • Updated on: 04/07/2018

    G. Elsafi et al. Department of Gastroenterology, Mercy University Hospital - Leading Edge 2018 Issue 1

    Open File
  • Calprotectin Home vs. Laboratory Test

    • PDF size: 6.92KB
    • Updated on: 04/07/2018

    Biochemistry Department, Mercy University Hospital - Case Study from Leading Edge 2018 Issue 1

    Open File
  • IBDoc® Self-care/Point of care Calprotectin Test: Early Value in a District General Hospital Inflammatory Bowel Disease Service

    • PDF size: 11.64KB
    • Updated on: 04/07/2018

    ECCO 2018 Poster: P. Avery and R. Wilson, Dorset County Hospital Foundation Trust

    Open File
  • Evaluation of the BÜHLMANN fCAL Turbo Faecal Calprotectin Assay on the Abbott Architect C8000. Comparison to the Phadia EliA and the IBDoc® home test kit.

    • PDF size: 1.43MB
    • Updated on: 04/07/2018

    MSc Research Project Scientific Paper, Mary O’ Connell, Eithne Barden, Biochemistry Laboratory, Mercy University Hospital, Cork, Republic of Ireland.

    Open File
  • Cost effectiveness of IBDoc as a surrogate marker of mucosal healing in IBD patients....

    • PDF size: 11.26KB
    • Updated on: 04/07/2018

    Elsafi et al. Mercy University Hospital

    Open File
  • IBDoc® Calprotectin Patient Self Test Results Correlate Well with Clinical Data

    • PDF size: 9.35KB
    • Updated on: 04/07/2018

    Dr. Alissa Walsh, John Radcliffe Hospital, Oxford

    Open File
  • Agreement Between Home-Based Measurement of Stool Calprotectin and ELISA Results for Monitoring Inflammatory Bowel Disease Activity

    • PDF size: 1.75MB
    • Updated on: 03/08/2018

    Heida et al. Clin Gastroenterol Hepatol. 2017 Jun 10

    Open File
  • Home Smart-phone Based Measurement of Fecal Calprotectin by IBD patients

    • PDF size: 11.67KB
    • Updated on: 03/08/2018

    Ungar B. et al Poster ECCO 2017

    Open File
  • Home vs Hospital-based Analysis of Stool Calprotectin Comparison of Two Monitoring Methods

    • PDF size: 11.06KB
    • Updated on: 03/08/2018

    Heida A. et al. Poster ECCO 2017

    Open File
  • Usability of a Home-based Test for the Measurement of Fecal Calprotectin in IBD Patients

    • PDF size: 11.64KB
    • Updated on: 03/08/2018

    Poster from ECCO 2017

    Open File
  • Home testing for faecal calprotectin: follow-up results from the first UK trial

    • PDF size: 8.66KB
    • Updated on: 04/07/2018

    Raker et al. King's College NHST Poster ECCO 2017

    Open File
  • Home-testing of faecal calprotectin using the IBDoc™ system: a comparative pilot study

    • PDF size: 510.95KB
    • Updated on: 04/07/2018

    King's College Hospital NHS Foundation Trust

    Open File
  • Calprotectin Patient Self-Testing in Practice

    • PDF size: 10.80KB
    • Updated on: 04/07/2018

    IBDoc Patient Feedback from Trials at Mercy Hospital, Cork

    Open File
  • Hope on the Horizon for IBD Patients

    • PDF size: 11.04KB
    • Updated on: 04/07/2018

    Crohn’s sufferer Lee Stanley from Manchester discusses his drive for calprotectin self-testing

    Open File
  • Usability Study of a Smartphone-Based Calprotectin Home Test

    • PDF size: 11.25KB
    • Updated on: 03/08/2018

    Open File
  • Usability study of a smartphone-based patient monitoring system measuring Calprotectin for therapy follow-up

    • PDF size: 11.68KB
    • Updated on: 03/08/2018

    Open File
  • Validation of a smartphone-based patient monitoring system measuring calprotectin as the therapy follow-up marker

    • PDF size: 12.11KB
    • Updated on: 03/08/2018

    Open File

Read the Patient Blog
IBDoc and Me

Colitis Monitoring Could Soon Start at Home
Gastroenterology and Endoscopy News: AUGUST 2015 | VOLUME: 66:8

Home-testing of faecal calprotectin using the IBDoc™ system: a comparative pilot study
Parr, H et al. King's College Hospital NHS Foundation Trust, Poster: BSG 2016,

An evaluation of patient satisfaction with IBDoc calprotectin home test system
Fitzgerald et al. Mercy University Hospital, Cork, Ireland: ECCO 2-17 Abstract N804

Usability of a home-based test for the measurement of fecal calprotectin in asymptomatic IBD patients
Bello et al. Dig Liver Dis. 2017 May 19. pii: S1590-8658(17)30886-1

“Usability scores for the home-based test were high. There was a very good correlation with the centrally measured FC by ELISA”.

Point of care testing of fecal calprotectin as a substitute for routine laboratory analysis
Hejl et al. Practical Laboratory Medicine Volume 10, March 2018, Pages 10-14

“We found a strong correlation coefficient of 0.887 between FC measured on IBDoc® and the laboratory assay BÜHLMANN fCAL® turbo”.

CalApp® is the smartphone app used with the IBDoc® Calprotectin Home Test. It is available for Android and iOS devices*.
As part of the IBDoc® System, CalApp® has been validated for the smartphones listed here.

*CalApp® is not available for download on non-validated phones and technical specifications or model nomenclature might differ in different countries.

Supported Apple Devices

Device Name  Model Number
iPhone 4s iPhone4,1
iPhone 5 iPhone5,1
iPhone 5s iPhone5,2
iPhone 5c iPhone5,3/iPhone5,4
iPhone 6 iPhone7,2
iPhone 6 plus iPhone7,1
iPhone 6s iPhone8,1
iPhone 7 iPhone9,1/iPhone9,3
iPhone 7 plus iPhone9,2/iPhone9,5
iPhone SE iPhone8,4
iPhone 8 iPhone10,4
iPhone X iPhone10,6
iPod Touch 5th Generation iPhone5G

Download the App 

Supported Samsung Devices 

Device Name  Model Number
Galaxy S3 GT-I9300/
Galaxy S3 Note SM-N9005
Galaxy S4 GT-I9505/
Galaxy S4 mini GT-I9195
Galaxy S5 SM-G900F
Galaxy S5 mini GT-I8200N
Galaxy S6 SM-G920F
Galaxy S7 SM-G930F
Galaxy S7 edge SM-G935F
Galaxy S8 SM-G950F
Galaxy S8 plus SM-G955F
Galaxy S9 SM-G960F
Galaxy S9 plus SM-G965F
Galaxy A3 (2014) SM-A300FU
Galaxy A3 (2016) SM-A310F
Galaxy A5 SM-A500FU
Galaxy A5 (2017) SM-A520F
Galaxy A8 (2018) SM-A530F
Galaxy J3 (2016) SM-J320F
Galaxy J5 (2017) SM-J530F
Galaxy J7 (2017) SM-J730F
Galaxy Core Prime LTE SM-G360F

Download the App 

Supported Alcatel Devices

Device Name  Model Number
OneTouch Idol3 6039Y

Supported HTC Devices

Device Name  Model Number

Supported Huawei Devices

Device Name  Model Number
P8 Lite ALE-L21
P10 VTR-L09
Honor 9e STF-L09
Nexus 6P Nexus 6P

Supported LGE Devices

Device Name  Model Number
LGE G3 LG-D855
LGE G4 LG-H815

Supported Motorola Devices

Device Name  Model Number
Moto G5 plus Moto G (5) plus

Supported Nokia Devices

Device Name  Model Number
Nokia 8 TA-1012

Supported One Plus Devices

Device Name  Model Number
OnePlus 3T ONEPLUS A3003
OnePlus 5T ONEPLUS A5010
OnePlus 6 ONEPLUS A6003

Supported Sony Devices

Device Name  Model Number
Xperia Z3compact E5823
Xperia Z5compact D58030
Xperia XA F5121

Supported Xiaomi Devices

Device Name  Model Number
Redmi Note 5 Redmi Note 5

The IBDoc® Portal is the web portal used by clinicians to help manage their IBDoc® patients and can be accessed via any standard web browser under

IBDoc Portal Minimal System Requirements

Operating System Software Version
iOS 5 or higher
Android 4 or higher
Web browser** Software Version
Chrome  20 or higher
Firefox  16 or higher
Internet Explorer 8 or higher
Safari 5 or higher
Microsoft Edge 1 or higher
Opera 20 or higher


IBDoc Frequently Asked Questions

  • Is the IBDoc available over the counter?
         No, it is only available through clinicians


  • Is the IBDoc available through private clinics?
    Clinics offering IBDoc for private testing:
    London Gastroenterology Centre
    Alexandra Guilfoyle Tel: 020 7183 7965 or email:


  • What if I upgrade my phone?
         If the phone is changed to another approved phone from the list then the same user ID and password will apply. 
         The local results history will be lost as this is stored on the phone, however it is still visible in the portal


  • What happens if I don’t have a WiFi connection?
         The result is stored until WiFi is re-established and then the result is sent to the portal


  • How secure is the data?
         There is a two way encrypted communication between the App and the portal with test results backed daily.
         No patient information is visible to anyone other than the clinic


  • What level are the traffic light thresholds set at?
         The categories are defaulted to:

IBDoc Thresholds

                  The levels are customisable by the clinician for each individual patient

  •  What happens if I get a red result?
         Contact the clinic using the information provided under the help/ contact information section for advice.

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