(R,R)-3,5-Bistrifluoromethylphenyl-NAS Bromide Maruoka chiral phase-transfer catalyst optically active spiro ammonium salt 100mg Wako

(R,R)-3,5-Bistrifluoromethylphenyl-NAS Bromide Maruoka chiral phase-transfer catalyst 100mg produced by FUJIFILM Wako Pure Chemical Corporation

Chiral phase-transfer catalysts, which are optically active spiro ammonium salts with 2 binaphthyl rings that allow for easy molecule designing, were invented by Professor Maruoka of the Kyoto University. (R,R)-3,4,5-Trifluorophenyl-NAS Bromide shows high catalytic activity and high enantioselectivity in asymmetric alkylation of alpha-amino acid derivatives ¹. By using (R,R)-3,5-Bistrifluoromethylphenyl-NAS Bromide, beta-hydroxy alpha-amino acid derivatives which are important chiral units of biologically active peptides are obtained in good yield by the aldol reaction of glycine derivatives with aldehydes. It was found that erythro isomers, which are major products, were obtained with high enantioselectivity ².

Features:
1. The rational molecular design of C₂-symmetric chiral quaternary ammonium salt
2. Reaction under mild organic / aqueous biphase conditions
3. Catalysing the asymmetric alkylations of alpha-amino acid derivatives and the direct asymmetric aldol reactions of glycine schiff base with aldehydes to the corresponding beta-hydroxy-alpha-amino acid derivatives

References:
1. Ooi T., Takeuchi M., Kameda M. and Maruoka K. : J. Am. Chem. Soc., 122 (21), 5228-5229 (2000).
2. Ooi T., Taniguchi M., Kameda M., Maruoka K. : Angew. Chem. Int.

Molecular Formula=C₆₀H₃₆BrF₁₂N
Molecular Weight=1078.82
Store at room temperature
For organic synthesis