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Pancreatic Elastase Assays

Easy and convenient screening for exocrine pancreatic insufficiency

Pancreatic insufficiency is the reduction of production or transportation of the digestive enzymes which results in the inability to properly digest a meal (fats, proteins and carbohydrates).

Pancreatic elastase is a proteolytic enzyme produced exclusively in the pancreas and is highly stable throughout the intestinal passage. Due to its high stability, the concentration of this enzyme can be measured in faeces to reflect the exocrine secretory capacity of the pancreas.

Applications

For many labs, the faecal elastase assay is the preferred test used to screen for exocrine pancreatic insufficiency, characterised by a low concentration of pancreatic elastase in faeces. Exocrine pancreatic insufficiency can be caused by numerous conditions, including: chronic pancreatitis, cystic fibrosis, diabetes mellitus, cholelithiasis, hereditary pancreatitis, chronic inflammatory bowel disease, pancreatic carcinoma, autoimmunologically caused pancreatitis, Shwachman-Diamond syndrome, autoimmune and connective tissue diseases, and Zollinger-Ellison syndrome.

The test is easy to perform, and convenient for patients as only one sample is required and the test is non-invasive. It has replaced the gold standard faecal fat test in most laboratories.

BÜHLMANN fPELA® Assay

The BÜHLMANN fPELA® assay for faecal pancreatic elastase utilises the same CALEX extraction device as the fCAL turbo assay, so it is possible to run both tests from a single extract.

The fPELA assay is random access and runs on standard clinical chemistry analysers (Roche, Abbott, Beckman, Siemens etc) although there is also the BioSystems BA 200, a stand-alone solution as well.

The assay is turbidimetric, with a dynamic range of 10 - 5000μg/g. Time to first result is 10 minutes with further results following every few seconds thereafter, making it one of the fastest faecal elastase assays available.

Results are comparable to the current ELISA based methods.

Literature

Case Studies

Pancreatic Elastase Assay Products

Faecal extraction set BÜHLMANN CALEX® Cap pre-filled with buffer, for patient sampling of faeces for calprotectin & elastase analysis.
Faecal extraction set BÜHLMANN CALEX® Cap pre-filled with buffer, for patient sampling of faeces for calprotectin & elastase analysis.
B-CALEX-CCSET25
Pack Size: 25
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Faecal elastase Immunoturbidimetric calibrators fPELA® turbo BÜHLMANN approx 100 tests to identify & monitor pancreatic insufficiency
Faecal elastase Immunoturbidimetric calibrators fPELA® turbo BÜHLMANN approx 100 tests to identify & monitor pancreatic insufficiency
B-KPELA-CASET
Pack Size: Each
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Faecal elastase Immunoturbidimetric controls fPELA® turbo BÜHLMANN approx 100 tests to identify pancreatic insufficiency & monitor disease
Faecal elastase Immunoturbidimetric controls fPELA® turbo BÜHLMANN approx 100 tests to identify pancreatic insufficiency & monitor disease
B-KPELA-CONSET
Pack Size: Each
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Faecal elastase Immunoturbidimetric reagents fPELA® turbo BÜHLMANN approx 100 tests to identify pancreatic insufficiency & monitor disease
Faecal elastase Immunoturbidimetric reagents fPELA® turbo BÜHLMANN approx 100 tests to identify pancreatic insufficiency & monitor disease
B-KPELA-RSET
Pack Size: Each
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