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Clinical Chemistry

Diagnostic Assays, Reagents and Controls

Alpha Laboratories is a trusted supplier of clinical chemistry reagents to healthcare professionals in the UK.

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Chemical Pathology or Clinical Biochemistry is the discipline that studies bodily fluids using a number of in vitro tests to provide clinicians with valuable information that can aid diagnosis. The use of certain biomarker screens can also be incorporated into testing regimes to exclude some patients from more invasive test procedures. 

The blood serves to transport oxygen, nutrients and hormones around the body and to defend against bacteria and viruses.  As such the levels of different proteins, antibodies and other analytes can provide information about how the body is functioning.  Dehydration and malnutrition can be investigated by looking at electrolytes and albumin. Organ injury can be indicated by the presence of tissue specific enzymes and the a build up of waste products that are normally removed e.g. bilirubin and hyaluronic acid. 

Serum Chemistry

The majority of our clinical chemistry assays are designed to analyse samples from blood, either using plasma or serum.  Plasma is prepared by collecting the blood into a vessel with an anticoagulant such as EDTA to prevent clotting and then spinning in a centrifuge so that the blood cells are collected at the bottom of the tube.  The plasma, the yellow liquid supernatant, is then drawn off for testing. 

Alternatively the blood can be collected without anticoagulant and allowed to clot before spinning in a centrifuge to separate the cells and liquid serum.  Unlike plasma, serum does not contain fibrinogen and certain clotting factors.

Biomarkers

Urine and stool samples are also important as these routes of elimination can also provide valuable information.  The kidneys filter blood and retain and reabsorb proteins, but when function is impaired protein may be excreted in the urine; detection of urine proteins can help diagnosis kidney diseases or monitor function in chronic conditions such as diabetes or hypertension. 

Whilst measurement of CRP in the blood can indicate inflammation it will not specify which tissues are involved as blood circulates throughout the body.  However measurement of the inflammation marker Calprotectin in stool samples gives information specifically about the bowel and as such can be used as a screening test to help distinguish between patients with functional disorders such as Irritable bowel syndrome (IBS) and those with suspected inflammatory bowel diseases (IBD) such as ulcerative colitis.  

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  • Assay Reagents

    Assay Reagents

    The full listing of our clinical chemistry assay kits
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  • Calibrators and Standards

    Calibrators and Standards

    Calibration and QC

    All quantitative assays need calibration to ensure accurate recovery and reporting.
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  • Controls

    Controls

    The use of quality control measures to validate assay performance is essential and controls should be run with every batch of samples. Assayed controls will give a target value and range in which the assay should recover.
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  • Dynex DS2® ELISA Processor

    Dynex DS2® ELISA Processor

    A Complete Walk Away System

    The Dynex DS2 can execute all functions associated with ELISA assay processing including sample/reagent dilution and addition, plate incubation and shaking, wash steps and OD measurement.

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  • Electrolytes

    Electrolytes

    Assays, calibrators and controls for electrolytes
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  • Enzymes

    Enzymes

    A wide range of assays for clinically significant enzymes
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  • Pregnancy Tests - hCG Assays

    Pregnancy Tests - hCG Assays

    The Immuno/hCG Detector kits are qualitative, solid phase, two site sandwich immunoassays for the detection of human chorionic gonadotropin (hCG) in urine or serum.
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  • Substrates

    Substrates

    A wide range of assays for substrates plus a selection of supporting calibrators and controls.
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  • Toxicology & Drugs of Abuse

    Toxicology & Drugs of Abuse

    Assays for the detection of alcohol, drugs and poisons.
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  • ISO 15189 Support

    ISO 15189 Support

    Help and support for laboratories implementing ISO 15189 accreditation.
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