Autoantibodies to GM1 in serum ELISA IgG and IgM separately 96 wells

Antibodies to ganglioside M1 IgG antibodies (GM1, anti-GM1) are implicated in the pathogenesis of Guillain-Barré Syndrome (GBS) and anti-GM1 IgM antibodies in multifocal neuropathy (MMN) and motor neuron disease (MND).
GM1 IgM antibodies may be present as monoclonal IgM paraprotein or as a polyclonal IgM. Polyclonal IgG may be detected in patients with motor neuropathies. High GM1 antibody titres may be detected in association with in Guillain-Barré Syndrome (GBS) following Campylobacter jejuni infection. The fact that GM1 is the only common Glycolipid antigen reactive with all of the GM1 antibodies found in motor nerve disorders suggests that it is the relevant target antigen in neural tissue.

The BÜHLMANN EK-GM1-GM ELISA quantifies the level of lgG and / or lgM isotypes of autoantibodies directed against GM1 in human serum. Titres of anti-ganglioside autoantibodies are expressed as % ratio of calibrator

Product Details:
Specimen Type: Serum. We recommend freezing aliquots of patient samples if you need to store samples in order to avoid repeated freezing/thawing. Store serum samples at –20°C up to 4 months. For long-term storage we recommend -70°C (samples are stable for >1 year). Frozen samples should be thawed and vortexed thoroughly prior to use.
Sample volume: 20µl
Isotype: IgG and IgM separate
Test type: Quantitative ELISA
Note@ Cold test conditions required
Time to Result: 4.5 hour
CE/IVD marked: Yes
Number of wells: 96 wells
Storage conditions: 2-8C. Do not freeze the calibrators or controls
Interpretative criteria:
Strongly positive: >100%
Positive: 50 - 100%
Intermediate: 30-50%