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Anti Sulfate-3-Glucuronyl Paragloboside (SGPG) autoantibody ELISA for serum BÜHLMANN 96 well plate
Product code: EK-SGPG
Pack Size: 96 Wells
CE Verified: CE IVD
Product Information
Anti-SGPG (sulfate-3-glucuronyl para-globoside) antibodies have a wider spectrum than anti-MAG antibodies - some patients which are anti-SGPG positive are negative for anti-MAG antibodies. Therefore, patients should be tested for both antibodies.
In general, antibodies recognizing MAG react with a carbohydrate determinant that is also present on an acidic lipid, sulfoglucuronyl paragloboside. In addition to the anti-MAG ELISA, the anti-SGPG ELISA enhances the chance to detect all neuropathies.
The anti-SGPG ELISA from BÜHLMANN is a semi-quantitative assay for determination of human IgM autoantibodies directed against sulfate-3-glucuronyl paragloboside (SGPG) and sulfate-3-glucuronyl-lactosaminylparagloboside (SGLPG). Interestingly, typical sensory demyelinating neuropathies have anti-MAG and anti-SGPG activities, whereas axonal neuropathies present only monoclonal IgM anti-SGPG activity. In humans, there seems to be a relationship between the titre of anti-MAG antibodies and the degree of demyelination.
The presence of anti-MAG/anti-SGPG antibodies is characteristic of a demyelinating neuropathy, whereas the presence of anti-SGPG antibodies alone seems to be more present in axonal non-demyelinating neuropathy, often of predominantly motor-type. Here again, the fine structure of the epitope recognized by the IgM may be involved. This is not an absolute relationship.
Product Details:
Specimen Type: Serum. Lipemic, hemolytic and icteric samples should not be used in this assay. Lipemic samples can be avoided by asking patients to fast for at least 12 hours prior to the sample being taken. Store serum samples at -20°C. Samples are stable for 1 year if stored at -20°C. Avoid repeated freeze-thaw cycles. Frozen samples should be thawed and mixed thoroughly by gentle swirling or inversion prior to use
Sample volume: 2µl
Test type: Semi Quantitative ELISA
Note@ Cold test conditions required
Time to Result: 5 hour
CE/IVD marked: Yes
Number of wells: 96 wells
Storage conditions: 2-8C
In general, antibodies recognizing MAG react with a carbohydrate determinant that is also present on an acidic lipid, sulfoglucuronyl paragloboside. In addition to the anti-MAG ELISA, the anti-SGPG ELISA enhances the chance to detect all neuropathies.
The anti-SGPG ELISA from BÜHLMANN is a semi-quantitative assay for determination of human IgM autoantibodies directed against sulfate-3-glucuronyl paragloboside (SGPG) and sulfate-3-glucuronyl-lactosaminylparagloboside (SGLPG). Interestingly, typical sensory demyelinating neuropathies have anti-MAG and anti-SGPG activities, whereas axonal neuropathies present only monoclonal IgM anti-SGPG activity. In humans, there seems to be a relationship between the titre of anti-MAG antibodies and the degree of demyelination.
The presence of anti-MAG/anti-SGPG antibodies is characteristic of a demyelinating neuropathy, whereas the presence of anti-SGPG antibodies alone seems to be more present in axonal non-demyelinating neuropathy, often of predominantly motor-type. Here again, the fine structure of the epitope recognized by the IgM may be involved. This is not an absolute relationship.
Product Details:
Specimen Type: Serum. Lipemic, hemolytic and icteric samples should not be used in this assay. Lipemic samples can be avoided by asking patients to fast for at least 12 hours prior to the sample being taken. Store serum samples at -20°C. Samples are stable for 1 year if stored at -20°C. Avoid repeated freeze-thaw cycles. Frozen samples should be thawed and mixed thoroughly by gentle swirling or inversion prior to use
Sample volume: 2µl
Test type: Semi Quantitative ELISA
Note@ Cold test conditions required
Time to Result: 5 hour
CE/IVD marked: Yes
Number of wells: 96 wells
Storage conditions: 2-8C
Specification
- Brand BÜHLMANN
- Sterile N
- CE Certified CE IVD
- Warranty Period Standard Terms Apply
- Is product classified as dangerous goods? No
- Does the product contain latex? Unspecified
- Shelf Life minimum 6 months
- Sensitivity NULL
- Application semi-quantitative in vitro diagnostic determination of human IgM-autoantibodies directed against sulfate-3-glucuronyl para-globoside [SGPG] and sulfate-3-glucuronyl-lactosaminyl-paragloboside [SGLPG]
- Specificity NULL
- Contents 12 x well microtitre plate, 3 x plate sealer, 1 x 100ml wash buffer concentrate (10x), 1 x 100ml incubation buffer, 1 vial calibrator, 3 vials controls, 1 x 11ml Enzyme label mix,1 x 11ml TMB substrate, 1 x 11ml stop solution
- Time Required 5 hours
Storage Details
- Pack Description 96 Wells
- Shipping Condition Ambient
- Storage Condition Fridge
- Pack Length (m) 0.22
- Pack Width (m) 0.16
- Pack Height (m) 0.11
- Pack Weight (kg) 0.50