Anti-Fy^a ALBAclone® (Human/Murine Monoclonal)

This Anti-Fya reagent is for the in vitro detection and identification of the human Fya blood group antigen by indirect agglutination. Anti-Fya and anti-Fyb were described in 1950 and 1951 respectively. FY*A and FY*B are a pair of alleles on the long arm of chromosome 1, giving rise to three commonly encountered phenotypes: Fy(a+b-), Fy(a+b+) and Fy(a-b+). Fya and Fyb antigens are destroyed when the red blood cells are treated with appropriate concentrations of the proteolytic enzymes ficin, papain, and α-chymotrypsin. When used by the recommended technique, this reagent will cause the agglutination (clumping) of red blood cells carrying the Fya antigen. Lack of agglutination demonstrates the absence of the Fya antigen. The main component of this reagent is derived from the in vitro culture of the IgG secreting human/murine heterohybridoma. The formulation also contains bovine material, potentiators and <0.1% (w/v) sodium azide.