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Aphidicolin tetracyclic diterpene antiviral antimitotic DNA polymerase alpha inhibitor 5mg Wako
Product code: 017-09813
Pack Size: 5mg
CE Verified: Research Use Only
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Product Information
Aphidicolin produced by FUJIFILM Wako Chemical Corporation
Aphidicolin is a biologically active substance produced by the fungus Cephalosporium aphidicola with antiviral and antimitotical activity. It is classed a natural tetracyclic diterpene. Ikegami et al. reported that aphidicolin shows specific inhibition of DNA synthesis in vivo, and Ohashi and Ikegami et al. demonstrated in in vitro studies that it specifically inhibits DNA polymerase alpha. The action of this product varies depending on the cells to which it is applied. In urchins, for example, the action of the product is limited to the phase of DNA synthesis (S phase), and its action can easily be removed by dialysis. Compared to the conventional inhibitors of DNA polymerase beta or of DNA polymerase gamma, for example ddTTP(2',3'-dideoxythymidine triphosphate), the product is considered to be highly specific. Compared to cell-synchronizing agents hydroxyurea and arabinosyl-cytidine, it is considered to be less cytotoxic making it useful for synchronizing cells at the S-phase.
Origin : Cephalosporium aphidicola ATCC 28300
Aphidicolin 5mg
Min content 99+% (Elementary Analysis)
Molecular Formula=C20H34O4
Molecular Weight: 338.48
CAS No: 38966-21-1
Store at 2-8°C
Aphidicolin is a biologically active substance produced by the fungus Cephalosporium aphidicola with antiviral and antimitotical activity. It is classed a natural tetracyclic diterpene. Ikegami et al. reported that aphidicolin shows specific inhibition of DNA synthesis in vivo, and Ohashi and Ikegami et al. demonstrated in in vitro studies that it specifically inhibits DNA polymerase alpha. The action of this product varies depending on the cells to which it is applied. In urchins, for example, the action of the product is limited to the phase of DNA synthesis (S phase), and its action can easily be removed by dialysis. Compared to the conventional inhibitors of DNA polymerase beta or of DNA polymerase gamma, for example ddTTP(2',3'-dideoxythymidine triphosphate), the product is considered to be highly specific. Compared to cell-synchronizing agents hydroxyurea and arabinosyl-cytidine, it is considered to be less cytotoxic making it useful for synchronizing cells at the S-phase.
Origin : Cephalosporium aphidicola ATCC 28300
Aphidicolin 5mg
Min content 99+% (Elementary Analysis)
Molecular Formula=C20H34O4
Molecular Weight: 338.48
CAS No: 38966-21-1
Store at 2-8°C
Specification
- Brand FUJIFILM Wako Chemicals Europe GmbH – Lab Chem
- Sterile N
- CE Certified Research Use Only
- Warranty Period Standard Terms Apply
- Is product classified as dangerous goods? No
- Does the product contain latex? Unspecified
- Source Species Cephalosporium aphidicola
- CAS Number 38966-21-1
- Application Biochemistry research
- Molecular Formula C20H34O4,
- Form 5mg
- Concentration min 99% content
- Purity NULL
- Marketed Grade Biochemistry Grade
- Molecular Weight 338.48
- Shelf Life NULL
- Species Reactivity NULL
- Preparation Form Powder
Storage Details
- Pack Description 5mg
- Shipping Condition Blue Ice
- Storage Condition Fridge
- Pack Length (m) 0.05
- Pack Width (m) 0.035
- Pack Height (m) 0.12
- Pack Weight (kg) 0.00
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