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Neutrophil Gelatinase Associated Lipocalin (NGAL) assays

NGAL ELISAs for measurement in humans and all five standard animal models of basic research, medical research and drug development. A new assay specifically detects the monomeric form NGAL which is associated with Acute Kidney Injury.

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Establish Toxicity Early

Establishing safety of new drug candidates remains a major challenge at every stage of the development process. 

However, it is important to identify failures early on so that resources can be diverted to drugs that are more likely to succeed.

"One of the primary reasons for the attrition of promising therapeutic agents from the drug development pipeline is the observation of treatment-related histologic injury to the kidney in animal toxicology studies." 
Olson et. al. 2009: Accelerating the Development of Biomarkers for Drug Safety

Faster Identity of Acute Kidney Injury (AKI)

Traditional methods for studying nephrotoxicity such as creatinine measurement may not be the best available as they can take two to three days and may be unreliable. 

NGAL (neutrophil gelatinase-associated lipocalin) is a novel biomarker for identifying Acute Kidney Injury (AKI). After such injury, NGAL levels rise quickly and markedly in both urine and blood, showing a wide response range in comparison with other proposed biomarkers of kidney injury.
Its measurement can detect kidney damage within 2 hours of onset.

NGAL shows a proportionate response to injury, hence, it can also be used to detect improvements in kidney condition.

Important Applications of NGAL Measurement for the Pharmaceutical Industry

The applications of BioPorto's animal NGAL ELISA kits in drug development range from drug discovery to pre-clinical toxicity testing.
They can be used in pre-clinical studies to detect rises in NGAL concentrations in urine and blood and hence the extent of renal injury, including nephrotoxic injury.

  • Safety biomarker 
    NGAL levels rise from baseline if the kidney is injured
  • Efficacy biomarker
    NGAL levels fall if kidney damage is treated effectively

 

 

The unique range of BioPorto NGAL ELISAs available from Alpha Laboratories includes kits for Mouse, Rat, Dog, Pig, Monkey and Human NGAL.

Human Total NGAL ELISA (Now CE Marked)

  • Sample: Urine, plasma, serum, tissue extracts or culture media
  • Up to 40 samples in duplicate
  • Range: 10-1000pg/ml
  • Assay time < 4h

Human NGAL monomer ELISA (Research Use Only)

  • Sample: Urine, plasma, serum, tissue extracts or culture media
  • Up to 40 samples in duplicate
  • Range: 10-1000pg/ml
  • Assay time < 4h

Mouse NGAL ELISA (Research Use Only)

  • Sample: Urine, plasma, serum, tissue extracts or culture media
  • Up to 40 samples in duplicate
  • Range: 10-1000pg/ml
  • Assay time < 4h

Mouse NGAL ELISA

 

Rat NGAL ELISA (Research Use Only)

  • Sample: Urine, plasma, serum, tissue extracts or culture media
  • Up to 40 samples in duplicate
  • Range: 4-400pg/ml
  • Assay time < 4h

Rat NGAL ELISA

 

Dog NGAL ELISA (Research Use Only)

  • Sample: Urine, plasma, serum, tissue extracts or culture media
  • Up to 40 samples in duplicate
  • Range: 4-400pg/ml
  • Assay time < 4h

DOG NGAL ELISA

 

Pig NGAL ELISA (Research Use Only)

  • Sample: Urine, plasma, serum, tissue extracts or culture media
  • Up to 40 samples in duplicate
  • Range: 10-400pg/ml
  • Assay time < 4h

Pig NGAL ELISA

 

Monkey NGAL ELISA (Research Use Only)

  • Sample: Urine, plasma or  serum
  • Up to 40 samples in duplicate
  • Range: 10-1000 pg/ml
  • Assay time < 4h

Monkey with Kidney

 

  • Animal NGAL Scientific References

    • PDF size: 10.48KB
    • Updated on: 04/07/2018

    Open File
  • Human NGAL Scientific References

    • PDF size: 9.79KB
    • Updated on: 04/07/2018

    Open File
  • NGAL - Improve Kidney Research

    • PDF size: 10.43KB
    • Updated on: 04/07/2018

    Neutrophil gelatinase-associated lipocalin is a small, robust protein, which is released into and can be detected in both urine and blood upon kidney tubular damage.

    Open File
  • Pharma NGAL Flyer

    • PDF size: 7.50KB
    • Updated on: 04/07/2018

    Open File

 
BioPorto’s NGAL ELISA assays are ideal for use in both research and drug development. BioPorto has recently published a poster about the use of the monomer, homodimer and total NGAL assays. Click here to download the poster.
 

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