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FIT for Bowel Cancer Screening and Symptomatic Testing

FIT for Bowel CancerFIT Provides Better Sensitivity and Specificity
for Colorectal Cancer Detection

Alpha Laboratories has been at the forefront of faecal testing in the UK for over 20 years. This was initially as the market leader for the guaiac-based test for faecal occult blood in stool in hospital laboratories. Tender wins for bowel cancer screening in all four UK countries followed this, as each launched its own colon cancer screening programme, assessing the average risk in asymptomatic populations.

Continuing to provide leading edge products, Alpha Laboratories has been awarded the first contract for the quantitative faecal immunochemical test (FIT) as the front line test in the Scottish Bowel Cancer Screening Programme. This will employ the Kyowa Medex HM-JACKarc system. England will also be moving to a quantitative FIT test for colon cancer in the NHS Bowel Cancer Screening Programme in the near future, for which Alpha Laboratories was successful in the tender for a framework agreement. 

The Faecal Immunochemical Test is more sensitive for colorectal cancer and advanced adenomas. FIT selectively detects the human globin-protein in stool, making it specific to colonic blood loss.

In addition to colorectal cancer screening, the use of FIT in the assessment of symptomatic patients is changing too, as more publications have demonstrated that its use as a "rule-out" test has benefits to clinicians, laboratories and patients. In this respect FIT has the potential to reduce the colonoscopy workloads and waiting times and avoid the need to for many patients to undergo this stressful and risky procedure.

Visit our new dedicated website to find out more about Faecal Immunochemical Testing:

NICE Diagnostic Guidance DG30 recommends quantitative faecal immunochemical tests
to guide referral for colorectal cancer in primary care

The new NICE DG30 guidance recommends that quantitative faecal immunochemical tests are

adopted in primary care to guide referral for suspected colorectal cancer in people without rectal bleeding, who have unexplained symptoms, but do not meet the criteria for a suspected cancer pathway referral outlined in NICE's guideline on suspected cancer

Results should be reported using a threshold of 10 micrograms of haemoglobin per gram of faeces. 

In the evidence review, HM-JACKarc was reported with 100% sensitivity, 76.6% specificity, 6.1% positive predictive value and 100% negative predictive value for colorectal cancer.

[FIT] assays were also cost effective when compared with no triage, with the HM-JACKarc dominating (that is, it was more effective and less expensive)

This new resource provides a repository of information for all those involved in FIT. Experiential case studies, plus videos of presentations, provide access to expertise from key opinion leaders in the field. With pages tailored to each part of the patient pathway, an extensive list of literature, publications, resources, related news and events that are regularly updated, it is the number one resource for FIT in the UK and Eire.

Here's what you'll find on

Benefits of FIT:

Alpha Laboratories set up this dedicated website to raise awareness amongst clinicians, laboratories, patients and the public, about advances in the detection of colorectal cancer using the faecal immunochemical test (FIT) and how it benefits these groups idividually.

Find out more about the benefits of FIT Testing

HM-JACKarc Automated Faecal Immunochemical Test System:

FIT test with HM-JACKarc systemAlpha Laboratories offers an automated quantitative solution for FIT with the Kyowa Medex HM-JACKarc system. 

HM-JACKarc offers fully automated testing on a compact bench top system, excellent sensitivity at the low end and simple, hygienic sample collection for patients.


Find out more about Automated Quantitative Faecal Immunochemical Testing


‘FIT to Practice?’ Workshop – ACB Focus – June 2018


FIT Negative Follow up – Dr James Turvill


Focus on FIT Issue 2

Focus on FIT


Focus on FIT Issue 1

Focus on FIT


Services - FIT for All:

Alpha Laboratories can provide a range of products and FIT services to help you develop your programme, tailored to your specific requirements. From instructions to logistics, Bowel Cancer Specialists are on hand to help you create the ideal solution.

Find out more about FIT services

Latest News:

Keep up to date with the latest news and updates relating to Faecal Immunochemical Testing.

See the latest news


See which upcoming events Alpha Laboratories will be attending, plus watch videos and presentations from previous conferences and our own Digestive Diseases Day.

Visit the events page

Hold a Free FIT Seminar:

You and your colleagues can learn about the clinical benefits of FIT, the patient pathways, different quantitative FIT systems and sample collection methods, with a FREE on-site seminar from Alpha Laboratories' technical specialist.

Request a FREE FIT Seminar