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MycoDDR™ for Recovery of Mycobacterium

MycoDDR

Digestion/Decontamination Reagents for Clinical Samples.

Maximise the recovery of Mycobacteria such as Mycobacterium tuberculosis.

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The clinical microbiology laboratory is often tasked with the analysis of samples to check for the presence of Mycobacteria such as Mycobacterium tuberculosis. However, such samples often originate from parts of the body where other bacteria are present. Since Mycobacteria are slow growing and require relatively lengthy incubation times for detection, the faster growth of other bacteria can obscure the presence of Mycobacteria preventing their detection in the sample. To avoid this, samples submitted for Mycobacteriology must first be digested (to release the Mycobacteria from the tissue or sputum) and decontaminated (to remove other micro-organisms).

The MycoDDR™ kit empowers labs to maximize the retention of viable Mycobacteria via rigid pH control throughout the digestion/decontamination process. It features an integrated pH indicator, which gives the user confidence that the correct pH has been maintained throughout the process, essential for optimal recovery of Mycobacteria.

All the high quality reagents are supplied pre-measured and ready to use so that both consistency and convenience can be ensured.

Rigid pH control leads to:

  • Cleaner smears
  • Culture results obtained faster
  • Fewer specimens to reprocess
  • Retention of viable Mycobacteria is maximized.

The indicator used is blue so that labs can maintain the correct pH throughout the treatment process by means of a visual confirmation. As the indicator is blue in colour (rather than the red used in other products) this means that pH can easily be monitored even in bloody samples.

In addition, the 10ml sample capacity of the MycoDDR™ kit means it is able to handle larger sample volumes than other kits on the market. This avoids the need to split samples for processing and so incur additional costs.

MycoDDR™ has also been designed so that the risk of cross-contamination of samples is decreased since the buffers are packaged in single use bottles. This feature minimises the risk of a false-positive result and a potentially erroneous diagnosis of tuberculosis. The Resuspension Buffer C enables labs to obtain a clean, uniform pellet with a pH between 6.8-7.2, which ensures the sample will be accepted in the sensitive environment for all rapid automated growth detection instruments.

The introduction of the MycoDDR™ kit to the laboratory can simplify workflow, improve quality and increase confidence in results - and thus diagnosis.

Reduced Risk of Cross-Contamination

The MycoDDR™ reagents are put through a rigorous sterilization/filtration process, and are packaged in a manner that requires minimal handling. Additionally, both the Neutralization Buffer B and the Resuspension Buffer C are provided in single-use bottles to minimize potential contamination introduced from a common-use container.

Easy to Process Specimens Containing Blood
Treating bloody specimens with the MycoDDR™ is easy because of the unique, blue color of the NALC-NaOH solution (see video examples in “Videos” tab). When the NALC-NaOH is added to a sample specimen containing blood, the solution turns purple. Then as the neutralization buffer is added, it is easy to see the color change from purple to light pink. At this point, the lab technician knows the solution has been properly neutralized.

Reduce Sample Splitting Workload
Unlike other commercial reagents that require splitting samples greater than 6-7 milliliters, the MycoDDR™ is able to fully support specimens up to 10 milliliters, due to the advanced buffering capacity of the Neutralization Buffer B. This feature drastically reduces the number of samples that need to be split, leading to increased efficiency and considerable cost savings to the lab.

Ease-of-use
Tired of mixing, weighing, and preparing digestion/decontamination reagents? The MycoDDR™ reagents are individually packaged, premeasured, and ready-to-use. The NaOH Reagent A is stable for 72 hours after the NALC is added, which gives labs the opportunity to conserve reagents and save on material costs. Also, implementing the MycoDDR™ eliminates user variability, reducing the chances for technical error and allowing samples to be easily processed on all shifts. There are multiple packaging options available for labs of all sizes—from a small lab running a few specimens per day to public health or reference labs processing hundreds of specimens per day.

  • Clinical evaluation of IMMY MycoDDR™

    • PDF size: 9.82KB
    • Uploaded on: 21/09/2015

    Open File
  • Myco DDR™ pH Overview

    • PDF size: 11.48KB
    • Uploaded on: 21/09/2015

    Rigid pH control leads to greater retention of viable Mycobacteria

    Open File
  • Myco DDR™ Trident Flyer

    • PDF size: 9.14KB
    • Uploaded on: 17/03/2017

    Open File

Ordering Information

The reagents come ready-to-use and the Neutralization Buffer B and Resuspension Buffer C are packaged individually (1 bottle of each per specimen). This drastically reduces the risk of cross-contamination, and also leads to virtually no preparation time being required The MycoDDR™ Trident format is available with either a 2.5% or 3% NaOH solution supplied.  Use of the 3% solution is advised for use with samples collected several hours or days before processing.
 

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