Non-invasive urine test for MCM5 to aid bladder cancer diagnosis.
The ADXBLADDER test is based on measuring levels of a protein called MCM5 (minichromosome maintenance protein 5) which is used during replication of cells. MCM5 is only found in cells that still have the capability to replicate (i.e. are not terminally differentiated).
Such cells are normally only found in basal layers of the epithelium, but when a mass of replicating cells is present (as occurs in bladder cancer), cells containing MCM5 are then shed into body fluids. Under normal circumstances MCM5 should not be found in the urine.
ADXBLADDER can be used to detect minichromosome maintenance protein 5 (MCM5) in human urine to aid detection of bladder cancer in patients presenting with haematuria and/or recurrent lower urinary tract symptoms with a suspicion of malignancy.
Bladder cancer is traditionally diagnosed using cystoscopy. Tumour morphology (small flat lesions) and location (uretic orifices, in ureters and folds of the bladder) can make identification by cystoscopy difficult, using ADXBLADDER as an adjunct test can aid diagnosis of cancers that may otherwise not be identified during routine investigations.
Stoeber K et al. Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments.
JNCI94 (14) 1071 (2002).
Diagnostics Kits - Information for the Public
Alpha Laboratories is a supplier of diagnostic kits for use by professional medical personnel within a clinical laboratory or doctors surgery. They are sold only to professionals for use in medical diagnostic or screening programmes. They are not available to the general public for home testing. This is to ensure correct procedures are followed, avoid potential interference from procedural or clinical conditions and certify accurate interpretation of results. As such these tests are not validated for use by non professionals.
For any concerns you may have please consult with your GP who should be able to advise you.
Alternatively the following websites may provide additional help:
NHS Choices Bladder Cancer
Fight Bladder Cancer
Action Bladder Cancer UK
Bladder and Bowel Community