Platelet agonist TRAP-6 amide for research use only

TRAP-6 amide is a synthetic PAR 1 (Thrombin Receptor Activating Peptide): H-Ser-Phe-Leu-Leu-Arg-Asn-NH2. TRAP-6 is a lyophilized preparation of TRAP-6 amide. The working concentration of the reconstituted reagent is 150μM.
Thrombin receptor activating peptide-6 (TRAP-6) activates platelets through the thrombin receptor protease activated receptor-1 (PAR-1).

Binding of TRAP-6 to PAR-1 causes a conformational change in the GPIIb/IIIa receptors on platelets, giving them high affinity for fibrinogen. Fibrinogen then binds to the receptors, crosslinking several platelets and causing aggregation.

Aggregation in TRAPtest may be reduced or absent in Glanzmann's thrombasthenia, where GPIIb/IIIa receptors are few or absent, or if the patient is taking a GPIIb/IIIa antagonist.

TRAPtest has only minor sensitivity for inhibition of COX1 and ADP-receptors