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YNT-185 Dihydrochloride Hydrate non-peptide Orexin receptor 2 agonist 5mg Wako
Product code: 254-00641
Pack Size: 5mg
CE Verification: Research Use Only
- List Price
- £347.75
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Product Information
YNT-185 Dihydrochloride Hydrate produced by FUJIFILM Wako Chemical Corporation
Orexins are a family of neuropeptides, which are secreted by orexin-producingnerve present in the hypothalamus. There are two variants, orexin receptors exist as two types of receptors, type 1 and type 2. In particular, the orexin 2 receptor is involved in sleep-wake regulation, and orexin deficiency in the brain causes narcolepsy, a sleep disorder manifesting as an unbearable sleepiness during the day. Although it has been reported that intraventricular administration of orexin leads to symptom alleviation in narcolepsy mouse models, therapeutic effects cannot be expected unless it is administered into the brain, due to orexin being a peptide and being unable to pass through the blood-brain barrier. Intraventricular or intraperitoneal administration of YNT-185·2HCl has been shown to extend wake time, and has also been reported to improve the symptoms of narcolepsy mouse models.
Molecular formula: C33H37N5O5S·2HCl·nH2O
Molecular weight: 688.66 (C33H37N5O5S·2HCl)
CAS No: 1804978-82-2 (anhydride)
Store at -20°C
Orexins are a family of neuropeptides, which are secreted by orexin-producingnerve present in the hypothalamus. There are two variants, orexin receptors exist as two types of receptors, type 1 and type 2. In particular, the orexin 2 receptor is involved in sleep-wake regulation, and orexin deficiency in the brain causes narcolepsy, a sleep disorder manifesting as an unbearable sleepiness during the day. Although it has been reported that intraventricular administration of orexin leads to symptom alleviation in narcolepsy mouse models, therapeutic effects cannot be expected unless it is administered into the brain, due to orexin being a peptide and being unable to pass through the blood-brain barrier. Intraventricular or intraperitoneal administration of YNT-185·2HCl has been shown to extend wake time, and has also been reported to improve the symptoms of narcolepsy mouse models.
Molecular formula: C33H37N5O5S·2HCl·nH2O
Molecular weight: 688.66 (C33H37N5O5S·2HCl)
CAS No: 1804978-82-2 (anhydride)
Store at -20°C
Specification
- Brand FUJIFILM Wako Chemicals Europe GmbH – Lab Chem
- Sterile N
- CE Certified Research Use Only
- Warranty Period Standard Terms Apply
- Is product classified as dangerous goods? No
- Does the product contain latex? Unspecified
- Source Species NULL
- CAS Number 1804978-82-2
- Application Cell biology
- Molecular Formula C33H37N5O5S·2HCl·nH2O
- Form 5mg
- Concentration NULL
- Purity Minimum 98.0% by HPLC
- Marketed Grade Cell Biology
- Molecular Weight 688.66
- Shelf Life NULL
- Species Reactivity NULL
- Preparation Form White - pale brown crystalline powder
Storage Details
- Pack Description 5mg
- Shipping Condition Dry Ice
- Storage Condition -20
- Pack Length (m) 0.1
- Pack Width (m) 0.1
- Pack Height (m) 0.1
- Pack Weight (kg) 0.00