Faecal Testing - Calprotectin

Calprotectin, when elevated in faeces, is a proven biomarker for organic, inflammatory bowel diseases (IBD) such as Ulcerative Colitis (UC) and Crohn's Disease (CD)¹. Inflammatory bowel conditions require further investigation by colonoscopy, treatment regimes and can be the precursor to fatal intestinal cancers.

Irritable Bowel Syndrome (functional disease) does not have an inflammatory component and can be treated by changes in lifestyle and diet. Typically, Irritable Bowel Syndrome does not require colonoscopy and/or treatment regime.

Reference: 1. Tibble J A et al. (2002) Use of surrogate markers of inflammation and Rome Criteria to distinguish organic from non-organic intestinal disease.  Gastroenterology 123:450-460.

Calprotectin ELISA

ELISA kit intended for the extraction and quantitative in vitro determination of human calprotectin (MRP8/14) in stool samples.

Main applications of the Calprotectin ELISA.

Differential Diagnosis: The assay offers an excellent negative predictive value enabling non-invasive differentiation between organic IBD and IBS.

Therapy Monitoring: To measure decrease of faecal MRP8/14 concentrations during successful therapy for IBD

Relapse Prediction: Increase of faecal MRP8/14 is an indicator for IBD relapses in the near future.

Features & Benefits:

• Rapid ELISA system (total ELISA time is 75 minutes)
• All reagents are ready to use*
• Kit includes calibrators and controls
• Analytical Sensitivity: <10µg/g Calprotectin in faecal sample
• Established cut-off of 50µg/g
• Measurable range 30-1800µg/g or 10-600µg/g**

* except wash buffer

** depending on which protocol is used

Product Code	Description	Pack Size	Price	Pack Size
EK-CAL	Calprotectin ELISA	96 wells	£560.00

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Quantum Blue

Quantum Blue: A rapid quantitative low-throughput Calprotectin testing platform for discrimination between IBD & IBS.

Quantum Blue Applications

The primary application for this platform is to differentiate between organic IBD and IBS in patients who present with gastrointestinal symptoms (eg. abdominal pain, constipation). Calprotectin is markedly elevated in inflammatory diseases, but low in functional diseases such as IBS.

If your Calprotectin test request number is too low to achieve a reasonable turn around time, Quantum Blue provides a comprehensive, low cost, entry-level Calprotectin testing platform.

Features & Benefits.

Quantum Blue provides a comprehensive, low cost, entry-level Calprotectin testing platform :

• Based on established lateral flow technology
• Provides a quantitative measure of Calprotectin in faecal samples but in a rapid test format
• Simple and rapid extraction and test process
• Supplied with a dedicated reader
• Excellent correlation with the market leading Calprotectin ELISA: uses a consistent cut off value (50µg/g)
• Tests in the range 30-300µg/g Calprotectin in stool samples

Quantum Blue - Cick to view ordering information

Product Code.	Description	Pack Size	Price	Add to cart
LF-CAL20-RD	Quantum Blue: Calprotectin tests (20)	20 tests	£495.00
BI-POCTR-ABS	Quantum Blue Reader	1 Unit	£2,600.00

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Calprotectin Rapid Test (CalDetect)

A rapid, semi-quantitative Calprotectin test that can be used either in the laboratory or the clinic.

CalDetect is ideal for first line screening to immediately differentiate between IBD and IBS in symptomatic patients. CalDetect is a stand alone test and does not require laboratory infrastructure, additional devices or instruments.

A collection device is used to add a sample of faeces to the extraction buffer, which is then mixed and added to a test cassette.

• Fast & simple point-of-care test
• Rapid – result obtained within 10 min
• No requirement for specialist testing equipment

The performance characteristics of CalDetect have been proven similar to that of an established ELISA²

Reference: 2. Shastri Y et al. (2006) A prospective comparative study for new rapid bedside faecal Calprotectin test with an established ELISA to assess intestinal inflammation.  107^th Annual Meeting of AGA: Abstract No. S1314

PreventID CalDetect - click to view ordering information

Product Code	Description	Pack Size	Price	Add to Cart
KST11005	PreventID CalDetect	10 tests	£150.00

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