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Calprotectin, when elevated in faeces, is a proven biomarker for organic, inflammatory bowel diseases (IBD) such as Ulcerative Colitis (UC) and Crohn's Disease (CD)1. Inflammatory bowel conditions require further investigation by colonoscopy, treatment regimes and can be the precursor to fatal intestinal cancers.
Irritable Bowel Syndrome (functional disease) does not have an inflammatory component and can be treated by changes in lifestyle and diet. Typically, Irritable Bowel Syndrome does not require colonoscopy and/or treatment regime.
Reference: 1. Tibble J A et al. (2002) Use of surrogate markers of inflammation and Rome Criteria to distinguish organic from non-organic intestinal disease. Gastroenterology 123:450-460.
ELISA kit intended for the extraction and quantitative in vitro determination of human calprotectin (MRP8/14) in stool samples.
Main applications of the Calprotectin ELISA.
Differential Diagnosis: The assay offers an excellent negative predictive value enabling non-invasive differentiation between organic IBD and IBS.
Therapy Monitoring: To measure decrease of faecal MRP8/14 concentrations during successful therapy for IBD
Relapse Prediction: Increase of faecal MRP8/14 is an indicator for IBD relapses in the near future.
Features & Benefits:
* except wash buffer
** depending on which protocol is used
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Quantum Blue: A rapid quantitative low-throughput Calprotectin testing platform for discrimination between IBD & IBS.
The primary application for this platform is to differentiate between organic IBD and IBS in patients who present with gastrointestinal symptoms (eg. abdominal pain, constipation). Calprotectin is markedly elevated in inflammatory diseases, but low in functional diseases such as IBS.
If your Calprotectin test request number is too low to achieve a reasonable turn around time, Quantum Blue provides a comprehensive, low cost, entry-level Calprotectin testing platform.
Quantum Blue provides a comprehensive, low cost, entry-level Calprotectin testing platform :
A rapid, semi-quantitative Calprotectin test that can be used either in the laboratory or the clinic.
CalDetect is ideal for first line screening to immediately differentiate between IBD and IBS in symptomatic patients. CalDetect is a stand alone test and does not require laboratory infrastructure, additional devices or instruments.
A collection device is used to add a sample of faeces to the extraction buffer, which is then mixed and added to a test cassette.
The performance characteristics of CalDetect have been proven similar to that of an established ELISA2
Reference: 2. Shastri Y et al. (2006) A prospective comparative study for new rapid bedside faecal Calprotectin test with an established ELISA to assess intestinal inflammation. 107th Annual Meeting of AGA: Abstract No. S1314