UK Freephone Orderline: 0800 387732
International Orderline: +44 2380 487209
The Faecal Analysis System builds on our expertise in faecal testing with the aim of offering a single supply source for the major diagnostic tests in this area. In addition, we provide a new, state-of-the-art ELISA automate so that your laboratory can have a dedicated faecal analysis platform.
The Elisys Duo is a state-of-the-art, fully automated ELISA processor that can process up to three 96 well microtitre plates simultaneously. The Duo can execute all functions associated with ELISA assay processing including sample/reagent dilution and addition, plate incubation and shaking, wash steps and OD measurement. It has a newly designed software system for user-friendly operation.
Key features include:
Calprotectin is a heterodimeric calcium binding protein (MRP8/14), which is present in both neutrophils and monocytes. Calprotectin is released from these cell types at sites of active inflammation. Calprotectin is a proven biomarker for Inflammatory Bowel Diseases (IBD), such as Ulcerative Colitis and Crohn’s Disease, where levels are raised in faecal samples. Calprotectin allows for non-invasive discrimination between IBD and Irritable Bowel Syndrome (IBS). EK-CAL provides quantitative determination of Calprotectin in faecal samples.
PMN-Elastase is a serine protease that is released from human polymorphonuclear (PMN) granulocytes upon activation or degradation. PMN granulocytes are present at sites of inflammation in the gut and determination of PMN-Elastase levels in faecal samples can be used to assess IBD, especially Crohn´s disease. K6840 provides quantitative determination of PMN-Elastase in serum, seminal plasma and stool.
Elastase is a pancreatic enzyme that degrades connective tissue. Pancreatic elastase does not undergo any significant degradation during intestinal transit. Therefore, measurement of Faecal Elastase can be used to diagnose or exclude pancreatic insufficiency associated with chronic pancreatitis, cystic fibrosis, carcinoma of the pancreas, Diabetes mellitus type 1, Schwachman-Diamond syndrome and other pancreatic diseases. BS-86-01 provides quantitative determination of Pancreatic Elastase levels in faecal samples and can be supplied with faecal extraction tubes.
Clostridium difficile (C. difficile) can be part of the normal bacterial flora of the human intestinal tract, but can become an opportunistic pathogen when the intestinal tract has been compromised or altered. C. difficile often causes pseudomembranous colitis (PMC), an antibiotic-associated disease that progresses from mucosal inflammation to the formation of colonic pseudomembranes composed of matrix and cellular components. C. difficile produces two toxins - toxin A (an enterotoxin) and toxin B (a cytotoxin).
Helicobacter pylori (H. pylori) is a spiral bacterium and is associated with a variety of gastrointestinal diseases including gastritis, duodenal and gastric ulcers, non-ulcer dyspepsia, gastric adenocarcinoma and lymphoma. The organism is present in 95-98% of patients with duodenal ulcers and 60-90% of patients with gastric ulcers. ELISA assays to test for the presence of H. pylori antigen or to test for immune response to the bacteria (specific IgG or IgA antibodies) can be used to confirm infection and monitor treatment. This group of ELISA kits are quantitative and infection is confirmed by means of an assigned cut-off value.
A range of products are now available to simplify and assist the pre-analytical faecal extraction process. These are dedicated, specially designed products to minimise operator contact with the sample whilst optimising extraction of the analytical parameter.
Also, these ELISA assays typically use only small amounts of faecal sample (50-100mg) further reducing any unpleasantness to the operator.