The NGAL Test

Image of NGAL Test and Acute Kidney Injury (AKI)

 

NGAL Overview

NGAL (neutrophil gelatinase-associated lipocalin) is a novel biomarker for diagnosing acute kidney injury (AKI). The key advantage of NGAL is that it responds earlier than other renal status markers like serum creatinine and shows a proportionate response to injury. NGAL determination thus permits the early diagnosis and prognostic stratification of acute kidney injury.

 

The NGAL Test

The NGAL Test** is based on the principle of turbidimetry, which is used in a wide range of automated clinical chemistry analyzers. Turbidimetry is simple, fast and accurate, and addresses the wide demand for urgent NGAL determination in both urine and plasma.

  • Measuring range: 25 to 5,000 ng/mL
  • Security range: Up to 40,000 ng/mL
  • Specimens: Urine and EDTA plasma

 

Image of NGAL test vs ELISA results The NGAL Test vs. ELISA

The turbidimetric NGAL Test results show an excellent correlation with the results from BioPorto's NGAL ELISA Kit. 40 urine samples from ICU patients selected to cover a wide range of different NGAL concentrations were measured by The NGAL Test and by BioPorto's NGAL ELISA Kit.

 

Image of NGAL vs RIFLE criteria NGAL vs. RIFLE criteria

NGAL shows a proportionate response to kidney injury and is significantly increased in patients who develop acute renal failure. Urine and plasma NGAL were measured in 135 consecutive ICU patients and the maximal values grouped according to the RIFLE criteria for AKI diagnosis. Both urine and plasma NGAL values provide high diagnostic performance.

 

Clinical Application

Measuring NGAL in urine or plasma gives you information on AKI status that you need for rapid clinical decision making e.g. in the following settings:

  • For monitoring critically ill patients in intensive care
  • As a powerful triage tool in the emergency room setting
  • For predictive evaluation in renal transplantation
  • For preventive information on damage caused by nephrotoxic contrast agents

 

Ordering Information

Product Code Description Pack Size Price  
ST001CA NGAL Test Kit 1x35;1x7ml £2,450.00
ST002CA NGAL Test Calibrator Set 5x1ml £230.00
ST003CA NGAL Test Control Set 2 (3 x 1ml) £450.00

 

Find Out More About The NGAL Test


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  ** BioPorto's NGAL patent WO2006066587 covering the measurement of NGAL as a marker for acute kidney injury is issued in South Africa, New Zealand and Singapore and is approved for issue in Europe.