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Calprotectin Assay Range

Calprotectin Assay Range

Measurement of Faecal Calprotectin – Your Choice

The widest range of test formats for assessment within primary care, Gastroenterology clinics or the hospital laboratory.


Measurement of faecal calprotectin is considered a reliable indicator of inflammation and numerous studies show that while faecal calprotectin concentrations are significantly elevated in patients with IBD, patients suffering from IBS do not have increased calprotectin levels.

Such increased levels are shown to correlate well with both endoscopic and histological assessment of disease activity.

In 2013 NICE published it’s Diagnostics Guidance DG11 that recommended that faecal calprotectin testing be used to help doctors distinguish between IBDs, such as Crohn’s disease and ulcerative colitis, and non-inflammatory bowel diseases, such as IBS.

Clinical Applications

Differential diagnosis: Excellent negative predictive value enabling non-invasive differentiation between organic IBD and functional IBS.
Therapy monitoring: Ensure compliance and successful therapy by detecting a decrease in calprotectin levels.
Relapse prediction: An increase in calprotectin can be an indicator for possible IBD relapse in the future

Alpha Laboratories has a range of calprotectin test formats to best suit your needs.

  • Quantum Blue® Rapid Assays for Point of Care and low throughput use
  • fCal ELISA for higher throughput laboratory use with automation available on the Dynex DS2™ ELISA Processing System.
  • IBD patient home monitoring with the IBDoc system

The symptoms of organic inflammatory bowel disease (IBD) and those of functional disorders such as Irritable Bowel Syndrome (IBS) can be very similar in presentation.

Historically, clinical gastroenterologists have had to use invasive endoscopy to differentially diagnose between these conditions. Not only is this stressful for the patient it carries a certain risk and is costly and time consuming for the NHS.

Using faecal calprotectin testing screens out IBS patients with an in vitro test, preventing the need for unnecessary endoscopy procedures.

  • Calprotectin Brochure

    • PDF size: 10.60KB
    • Uploaded on: 21/09/2015

    Open File
  • Calprotectin Clinical Publications

    • PDF size: 10.55KB
    • Uploaded on: 24/03/2016

    Open File
  • fCAL turbo datasheet

    • PDF size: 9.48KB
    • Uploaded on: 29/01/2016

    Open File
  • NICE Diagnostics Guidance 11 - Calprotectin

    • PDF size: 4.62KB
    • Uploaded on: 18/09/2015

    Faecal calprotectin diagnostic tests for inflammatory diseases of the bowel

    Open File

Download the selection of Clinical Publications Summaries Document

Buhlmann Calprotectin Assays Literature References

1. Faecal Calprotectin: comparative study of the Quantum Blue® rapid test and an established ELISA method. Liselotte Coorevits, Filip J. Baert and Hilde J.M. Vanpouke 
Clin. Chem. Lab. Med. 2012; 51:4

2. Value of fecal calprotectin in the evaluation of patients with abdominal discomfort: an observational study. Manz et al.
 BMC Gastroenterology 2012; 12:5

3. Faecal Calprotectin: Validation of a Laboratory Marker for Intestinal Inflammation. L. Claerys, L.Moortgat, F. Baert, H. Vanpoucke. 
University of Gent Poster

4. Validation of a point-of-care desk top device to quantitate fecal calprotectin and distinguish inflammatory bowel disease from irritable bowel syndrome. Michael J. Sydora, Beate C. Sydora, Richard N. Fedorak. Journal of Crohn's and Colitis (2012) 6, 207-214

5. A New Rapid Quantitative Test for Fecal Calprotectin Predicts Endoscopic Activity in Ulcerative Colitis.Triana Lobatón Ortega, Francisco Rodríguez-Moranta, Jordi Guardiola Capón, Elena Sánchez Pastor, Lorena Rodríguez Alonso, Alexandra Ruiz Cerulla, Alicia López García. Department of Gastroenterology. Bellvitge University Hospital. Barcelona. Spain. DOI: 10.1097/MIB.0b013e3182802b6e

6. Calprotectin in biomarker-mediated drug development: Method validation for the quantification of fecal Calprotectin. Ronald Vermunt, Marcel van der Linden and Edwin Janssen. POSTER: Eurofins Medinet B.V., Department of Biomarkers & Biopharmaceuticals, Breda, The Netherlands

7. Evaluation of Prevent ID and Quantum Blue rapid tests for fecal calprotectin. Jan Hessels, Geke Douw, Duygu D. Yildirim, Gerrit Meerman, Margot A. van Herwaarden and Frank A.J.T.M. van den Bergh. Clin Chem Lab Med. 2012 Jan 13;50(6):1079-82. 

8. Monoclonal antibody testing for faecal calprotectin is superior to polyclonal testing of faecal calprotectin and lactoferrin to identify organic intestinal disease in patients with abdominal discomfort. Emanuel Burri, Michael Manz, Claude Rothen, Livio Rossi , Christoph Beglinger, Frank Serge Lehmann. Clinica chimica acta; international journal of clinical chemistry (Impact Factor: 2.76). 11/2012; 416.

Diagnostics Kits - Information for the Public

Alpha Laboratories is a supplier of diagnostic kits for use by professional medical personnel within a clinical laboratory or doctors surgery. They are sold only to professionals for use in medical diagnostic or screening programmes. They are not available to the general public for home testing.

Whilst some of the sample collection may be carried out at home, the performance of the tests and analysis of results must be done by professionals in a clinical environment. This is to ensure correct procedures are followed, avoid potential interference from procedural or clinical conditions and certify accurate interpretation of results. As such these tests are not validated for use by non professionals.

For any concerns you may have please consult with your GP who should be able to advise you.

Alternatively the following websites may provide additional help:

NHS Bowel Cancer Screening:

Bowel Cancer UK:

Lab Tests Online:

The IBS Network:

Crohn's and Colitis UK:

Crohn's Support:

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